Our research focus

Research in the Hodges lab focuses on gene regulation in cancer and normal cells. We use interdisciplinary approaches, including epigenomics, live-cell imaging, and chemical biology, to reveal new mechanisms related to chromatin and transcription. We are especially excited by emerging therapeutics related to cancer epigenetics and other areas with translational impact.

Chromatin and the epigenome

The chromatin landscape is the final integration site of cellular signals, and the main avenue by which the genome senses its environment. We have a special interest in SWI/SNF (BAF) and related ATP-dependent chromatin remodelers, which play key roles in malignancy and normal development. We aim to improve epigenetic therapies by identifying how these complexes influence signal integration and gene expression in normal and disease states.

Affiliations

We are proud members of Baylor College of Medicine, Rice Department of Bioengineering, and the MD Anderson Center for Cancer Epigenetics.

  • We study chromatin and transcription regulatory mechanisms, and reveal how these systems are disrupted in human disease.

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